Journal article
No evidence for PALB2 methylation in high-grade serous ovarian cancer
T Mikeska, K Alsop, G Mitchell, DD Bowtell, A Dobrovic
Journal of Ovarian Research | BIOMED CENTRAL LTD | Published : 2013
Abstract
Background: High-grade serous ovarian cancers are a distinct histological subtype of ovarian cancer often characterised by a dysfunctional BRCA/Fanconi anaemia (BRCA/FA) pathway, which is critical to the homologous recombination DNA repair machinery. An impaired BRCA/FA pathway sensitises tumours to the treatment with DNA cross-linking agents and to PARP inhibitors. The vast majority of inactivating mutations in the BRCA/FA pathway are in the BRCA1 and BRCA2 genes and occur predominantly in high-grade serous cancer. Another member of the BRCA/FA pathway, PALB2 (FANCN), was reported to have been inactivated by DNA methylation in some sporadic ovarian cancers. We therefore sought to investigat..
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Grants
Awarded by U.S. Department of Defense
Funding Acknowledgements
AD received funding from the National Breast Cancer Foundation Collaborative Breast Cancer Research Grant Program (CG-08-07) and the Cancer Council of Victoria. The Australian Ovarian Cancer Study was supported by the U.S. Army Medical Research and Materiel Command under DAMD17-01-1-0729, The Cancer Council Tasmania, The Cancer Foundation of Western Australia, the National Health and Medical Research Council of Australia (NHMRC; ID400413), and was approved by the Human Research Ethics Committees at the Peter MacCallum Cancer Centre, Queensland Institute of Medical Research, University of Melbourne and all participating hospitals. The Genotyping in the Australian Ovarian Cancer Study project was supported by the Ovarian Cancer Research Program of the US Department of Defense (W81XWH-08-1-0684 and W81XWH-08-1-0685) (DDLB and GM), Cancer Australia (DDLB and GM) and the National Breast Cancer Foundation (ID509303) (GM), the Peter MacCallum Cancer Centre Foundation (GM) and the Cancer Council Victoria (postgraduate scholarship for KA). We gratefully acknowledge the cooperation of the participating institutions in Australia, and also acknowledge the contribution of the study nurses, research assistants and all clinical and scientific collaborators. The complete AOCS Study Group can be found at www.aocstudy.org. We would like to thank all of the women who participated in the study.